Evaluation of a Cold-Recombinant Influenza Virus Vaccine in Ferrets
Identifieur interne : 002669 ( Main/Exploration ); précédent : 002668; suivant : 002670Evaluation of a Cold-Recombinant Influenza Virus Vaccine in Ferrets
Auteurs : H. F. Maassab [Géorgie (pays)] ; A. P. Kendal [Géorgie (pays)] ; G. D. Abrams [Géorgie (pays)] ; A. S. Monto [Géorgie (pays)]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1982.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (immunologie), Basse température, Cornets (microbiologie), Furets, Gènes viraux, Poumon (microbiologie), Recombinaison génétique, Réplication virale, Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (physiologie), Études d'évaluation comme sujet.
- MESH :
- génétique : Virus de la grippe A.
- immunologie : Antigènes viraux, Virus de la grippe A.
- microbiologie : Cornets, Poumon.
- physiologie : Virus de la grippe A.
- Animaux, Basse température, Furets, Gènes viraux, Recombinaison génétique, Réplication virale, Vaccins antigrippaux, Vaccins atténués, Études d'évaluation comme sujet.
English descriptors
- KwdEn :
- Animals, Antigens, Viral (immunology), Cold Temperature, Evaluation Studies as Topic, Ferrets, Genes, Viral, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (physiology), Influenza Vaccines, Lung (microbiology), Recombination, Genetic, Turbinates (microbiology), Vaccines, Attenuated, Virus Replication.
- MESH :
- chemical , immunology : Antigens, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- microbiology : Lung, Turbinates.
- physiology : Influenza A virus.
- Animals, Cold Temperature, Evaluation Studies as Topic, Ferrets, Genes, Viral, Influenza Vaccines, Recombination, Genetic, Vaccines, Attenuated, Virus Replication.
Abstract
Cold-recombinant strains of influenza virus were derived at 25 C using an attenuated cold-adapted (ca) and temperature-sensitive (ts) A/Ann Arbor/6/60 (H2N2) strain and wild-type (wt) strains of epidemic relevance. The cold recombinants were characterized in ferrets in terms of clinical manifestations, viral titers, and histopathologic lesions in turbinates and lungs. The data in ferrets showed that cold recombinants with six genes derived from the ca “master” strain and the two surface antigens of the wt parent strain were predictably attenuated and genetically stable. Attenuation of recombinants with an additional gene derived from the wt parent was less predictable. Recombinants possessing the nonstructural gene of the wt parent showed some reactogenicity at high doses, whereas cold recombinants with RNA 2 from the wt parent did not. A recombinant strain possessing RNA 7 of the wt parent showed reversion to the ts+ phenotype but remained attenuated. Similar results were obtained from testing the recombinants in humans.
Url:
DOI: 10.1093/infdis/146.6.780
Affiliations:
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F." last="Maassab">H. F. Maassab</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Departments of Epidemiology (School of Public Health) and Pathology (School of Medicine), University of Michigan, Ann Arbor, Michigan, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Departments of Epidemiology (School of Public Health) and Pathology (School of Medicine), University of Michigan, Ann Arbor, Michigan, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Abrams, G D" sort="Abrams, G D" uniqKey="Abrams G" first="G. D." last="Abrams">G. D. Abrams</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Departments of Epidemiology (School of Public Health) and Pathology (School of Medicine), University of Michigan, Ann Arbor, Michigan, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Monto, A S" sort="Monto, A S" uniqKey="Monto A" first="A. S." last="Monto">A. S. 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The cold recombinants were characterized in ferrets in terms of clinical manifestations, viral titers, and histopathologic lesions in turbinates and lungs. The data in ferrets showed that cold recombinants with six genes derived from the ca “master” strain and the two surface antigens of the wt parent strain were predictably attenuated and genetically stable. Attenuation of recombinants with an additional gene derived from the wt parent was less predictable. Recombinants possessing the nonstructural gene of the wt parent showed some reactogenicity at high doses, whereas cold recombinants with RNA 2 from the wt parent did not. A recombinant strain possessing RNA 7 of the wt parent showed reversion to the ts+ phenotype but remained attenuated. Similar results were obtained from testing the recombinants in humans.</div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li></country></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name></noRegion><name sortKey="Abrams, G D" sort="Abrams, G D" uniqKey="Abrams G" first="G. D." last="Abrams">G. D. Abrams</name><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name><name sortKey="Monto, A S" sort="Monto, A S" uniqKey="Monto A" first="A. S." last="Monto">A. S. Monto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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